The first knot is created by our attention becoming entangled with matter and materialism.
it starts from Muladhara, moves up to the left channel and created superego.
By its action we lose sight of the Spirit.
To overcome it we should put our attention on the Spirit and not on worldly matters.
The second knot is the one by which we think that we can “do” something and achieve something in this world.
The more we think and strive and live with out ambition. the more its action moves up to the right side and created ego.
Human beings cannot break the second knot, only God can do it.
So here we must respect ourselves and surrender ourselves to God.
The third and last knot occurs on the central channel due to artificiality in seeking.
We have to be truthful and honest in our seeking, absolutely on the truth.
We are seeking the Spirit, to become one with the Spirit and all our attention should go on the Spirit and should not be frittered away on nonsensical things.